..According to this article:
https://singularityhub.com/2022/02/22/f ... longevity/
“Two years of modest calorie restriction reprogrammed the pathways in fat cells that help regulate the way mitochondria generate energy, the body’s anti-inflammatory responses, and potentially longevity,” said study author Dr. Eric Ravussin. “In other words, calorie restriction rewires many of the metabolic and immune responses that boost lifespan and health span.”